What contributes to the severity changes in atopic dermatitis over time?

The severity changes in atopic dermatitis over time can be attributed to a combination of multiple factors, which include environmental factors, genetic predisposition, and age and hormonal changes.

Environmental factors play a significant role, as exposure to allergens, irritants, weather changes, and pollution can trigger or exacerbate symptoms. For instance, temperature fluctuations or contact with soaps, detergents, and other irritants can lead to flare-ups or alleviation of symptoms depending on the individual's environment.

Genetic predisposition is crucial as atopic dermatitis often runs in families, indicating a hereditary aspect. Individuals with a family history of allergies, asthma, or eczema are more likely to experience severe forms of atopic dermatitis due to inherited traits that affect skin barrier function and immune response.

Age and hormonal changes also contribute significantly to the condition's progression. For example, the severity of atopic dermatitis may fluctuate throughout life stages, particularly during puberty or pregnancy when hormonal changes can influence immune response and skin condition. Children may experience different patterns of eczema compared to adults, with some outgrowing the condition as they age, while others may see persistence or recurrence of symptoms into adulthood.

Thus, the interplay of these factors leads to variations in the severity of atopic dermatitis, making it a