What is a common complication associated with hyperuricemia in patients taking HCTZ?

Hyperuricemia, an elevated level of uric acid in the blood, is commonly seen in patients on hydrochlorothiazide (HCTZ), a thiazide diuretic often used in the management of hypertension and edema. One of the notable complications of hyperuricemia is the risk of developing gout due to the precipitation of uric acid crystals in the joints.

When focusing on hyperglycemia, it's important to recognize that thiazide diuretics, including HCTZ, can induce insulin resistance, leading to elevated blood glucose levels over time. This effect is particularly crucial for patients with pre-existing diabetes or metabolic syndrome, as they may find it more challenging to manage their blood sugar levels when on HCTZ.

In contrast, hypercalcemia, hypoglycemia, and hypertension do not typically result from hyperuricemia induced by HCTZ. While hypertension is the primary condition HCTZ is designed to treat, it is not a complication of hyperuricemia itself. Thus, the association between hyperuricemia and the potential for hyperglycemia makes it the correct choice in this context.