What is a potential side effect of Tricyclic Antidepressants (TCA) in elderly patients?

Tricyclic antidepressants (TCAs) are known for their anticholinergic properties, which can lead to various side effects, particularly in elderly patients who are often more sensitive to medications. One significant potential side effect of TCAs is the risk of arrhythmias. This is primarily due to the drug's ability to affect cardiac conduction.

Elderly patients may have pre-existing cardiovascular issues or age-related changes in cardiac function that make them more susceptible to the effects of TCAs. TCAs can prolong the QT interval and increase the risk of ventricular arrhythmias, which can be particularly dangerous for older adults. Monitoring heart health is essential when prescribing these medications to this population.

The other options do not specifically align with the well-documented side effects associated with TCAs in the elderly. While conditions like arthritis, hypertension, and diabetes can be prevalent in this age group, they are not directly caused by or typical responses to TCA use. Instead, arrhythmias are a recognized concern when managing older patients on these antidepressants, underscoring the need for careful assessment and monitoring when prescribing TCAs to the elderly.