What is the first-line treatment for GERD?

Proton pump inhibitors (PPIs) are recognized as the first-line treatment for gastroesophageal reflux disease (GERD). They work by significantly reducing gastric acid secretion, which helps to heal the esophagus and alleviate the symptoms associated with GERD, such as heartburn and regurgitation. PPIs are more effective than H2 blockers and antacids because they provide a longer duration of acid suppression, allowing for greater healing of esophageal erosion and reducing the frequency of reflux episodes.

While H2 blockers can be helpful and are indeed used for GERD management, they do not suppress acid production as effectively as PPIs. Additionally, antacids can provide quick relief for mild symptoms but do not address the underlying condition in the long term. Stool softeners have no relevance in the treatment of GERD as they are used for managing constipation. Therefore, the most appropriate first-line treatment for GERD remains proton pump inhibitors due to their efficacy in controlling symptoms and promoting esophageal healing.