What side effect should be monitored when using ASA long-term?

When using acetylsalicylic acid (ASA), commonly known as aspirin, long-term, one significant side effect to monitor for is tinnitus. Tinnitus, which is characterized by ringing or other noises in one or both ears, can occur as a result of the ototoxic effects of salicylates, especially at higher doses. This side effect is particularly relevant for patients who may be on prolonged therapy for cardiovascular prevention or other chronic conditions.

Monitoring for tinnitus is essential as it can indicate the onset of salicylate toxicity, especially in the context of long-term usage. Recognizing the signs early allows for timely intervention, such as dose adjustment or discontinuation of the medication, to prevent further complications.

While the other listed side effects—such as increased blood pressure, weight gain, and hair loss—may be associated with a variety of medications or conditions, they are not typically connected with long-term use of ASA in the same way that tinnitus is. Therefore, focusing on tinnitus as a critical side effect not only underscores the potential risks associated with ASA but also reflects an understanding of its pharmacological profile.