What symptom best describes Morton's neuroma?

Morton's neuroma is characterized by a specific pain sensation often described by patients as feeling like they are standing on a pebble or having a lump in the ball of their foot. This condition typically arises from the thickening of the nerve tissue between the third and fourth toes, leading to discomfort and sharp or burning pain in that area. Patients may also experience tingling, burning, or sharp pain when walking or wearing shoes that compress the forefoot.

This distinct sensation of standing on something uncomfortable makes it easier to identify Morton's neuroma, distinguishing it from other conditions that might cause foot pain or discomfort. Other options mention symptoms like numbness in the toes or swelling in the ankle, which do not directly correlate with the hallmark presentation of Morton's neuroma. Calf cramps during exercise, while concerning, are unrelated to the nerve compression seen in this condition. Thus, the option referencing the painful sensation akin to standing on a pebble best encapsulates the typical symptomatology associated with Morton's neuroma.