What virus is most commonly associated with Hand Foot Mouth disease?

Hand, Foot, and Mouth disease (HFMD) is primarily associated with the Coxsackie virus, specifically serotype A16, among others in the enterovirus family. This viral infection is most prevalent in young children but can also occur in adults. It is characterized by fever, sores in the mouth, and a rash on the hands and feet. Coxsackie viruses are notably responsible for these symptoms, as they invade the oral mucosa and skin.

The other viruses listed have different associated diseases. Herpes Simplex virus primarily causes herpes lesions, Human Papillomavirus is known for its association with warts and cervical cancer, and Varicella-Zoster virus causes chickenpox and shingles. Thus, Coxsackie virus is the clear and correct choice when discussing the etiology of Hand, Foot, and Mouth disease, highlighting its specific role as the causative agent in this common childhood illness.