Which effect can high doses of NSAIDs have on blood pressure?

High doses of NSAIDs (non-steroidal anti-inflammatory drugs) can indeed lead to an increase in blood pressure. This effect is primarily due to the mechanism by which NSAIDs inhibit the production of prostaglandins, which play a crucial role in regulating blood flow and kidney function. When NSAIDs block the production of these molecules, it can result in fluid retention and increased sodium reabsorption in the kidneys. This fluid retention can lead to increased blood volume, ultimately causing an elevation in blood pressure.

Furthermore, long-term use of NSAIDs can contribute to cardiovascular risks, including hypertension, especially in individuals who may already be predisposed to high blood pressure. The effect tends to be more pronounced in patients with existing hypertension or in those who are older, further reinforcing the need for careful monitoring of blood pressure in patients taking high doses of NSAIDs.

In summary, the correction of blood pressure increase from NSAID use aligns with pharmacological understanding and clinical observations, thereby confirming the correctness of the chosen answer.